Development and implication of methodology for aceclofenac in pure and pharmaceutical formulations by microwave assisted spectrophotometry

ABSTRACT

A simple, fast and cost effective method for determination of Aceclofenac in pure and tablet formulations has been developed and validated. The method is based on formation of stable blue coloured complex [lambda[max] = 740nm] of Aceclofenac with ammonium molybdate in presence of sulfuric acid under microwave irradiation for 5min. Peak shift in FT-IR spectra also indicated the formation of complex. Measurement of absorbance was carried out at lambda[max] = 740nm. The reaction obeys Beer's law over the concentration range of 50-250 micro g/ml of Aceclofenac. The RSD [intra-day and inter-day precision] for the drug is not greater than 0.95% and recoveries were found to be in range of 99.01-99.99%. The proposed method can be used successfully for routine analysis of Aceclofenac in pure and tablet formulations