Effect of metal ions on the antimicrobial activity of aminoglycoside class of antibiotics

ABSTRACT

A number of cobalt [II], nickel [II], copper [II] and zinc [II] complexes of aminoglycoside class of antibiotics such as, gentamycine and streptomycine have been synthesised The antimicrobial studies of these metal-antibiotic complexes against bacterial species staphylococcus aureus, staphylococcus proteus, pseudomonas aeruginosa, klebsiella pnemonae and escherchia coli have shown to be more active and antimicrobial than the pure uncomplexed antibiotics