Serum prostate specific antigen [PSA];In normal subjects and patients of benign prostatic hyperplasia and carcinoma prostate

ABSTRACT

To study correlation between age-linked serum prostate specific antigen [PSA] levels in normal subjects and patients of benign prostatic hyperplasia [BPH] and carcinoma prostate [CaP]. OPDs. Case-control study. SIUT; Karachi Six months. 250 subjects were enrolled for the study and 93 were finally selected [31 each, representing the normal, BPH and CaP groups]. Subjects 40 years of age and above were included and those with any urinary tract disorder orthose under treatment with 5-alpha-reductase inhibitors were excluded. Each group was divided into four sub-groups of ages 40-49, 50 - 59, 60 - 69 and 70 and above years. AxSYM total PSA [tPSA] assay_ was used tor serum PSA estimation. Values were expressed as mean and standard error of mean and Fischer's test, students' t test and correlation coefficient were used to determine significance and for comparison of data. There was a no significant difference in PSA levels in all age groups when normals were compared with BPH cases. PSA levels were significant in normal as compared to CaP cases and BPH as compared to CaR. No significant correlation between age-linked serum PSA levels in normal subjects and patients of BPH and CaP could be established. The study, however, found atrend of declining PSA levels at the age of 70 years and above