Association of transaminase levels with obesity, serum lipids, diabetes, smoking and level of physical activity

ABSTRACT

To determine the association of the serum transaminase levels in non-viral liver disorders and the underlying factors, including obesity, serum lipids, history of diabetes, and lifestyle factors, such as smoking and exercise/physical activity. This cross-sectional study was conducted in Medical OPD of Pakistan atomic energy complex [PAEC] Hospital, Islamabad from September, 2011 to February, 2012. Ninety six patients were selected by consecutive sampling after obtaining hospital ethical committee permission and informed written consent. Ratio of S-GOT/S-GPT was analyzed along with values of blood sugar fasting, Cholesterol, Triglycerides, Blood Pressure, Exercise/Physical Activity and Smoking by a semi structured questionnaire. The normal and abnormal values of Liver function tests were associated with the above mentioned investigations and Chi square test was applied. There were 5 [5.2%] patients who had elevated S-GOT value. There was significant association between S-GOT value and monthly income of the patients [p-value <0.029] but not in case of SGPT. Similarly Hepatitis B antigen also showed significant association with S-GOT [0.004] and SGPT level [0.03]. There was no significant relationship between normal or elevated SGOT/SGPT with triglycerides, cholesterol, blood sugar fasting [BSF], blood pressure, practice of regular exercise and smoking status of patients. Raised liver enzymes are associated with positive Hepatitis B antigen and socioeconomic status of patients