Can preoperative serum level of creatinine predict new-onset atrial fibrillation in non-diabetic male patients undergoing open heart surgery? A retrograde view

ABSTRACT

Renal dysfunction is a risk marker in patients who candidate for coronary artery bypass graft [CABG]. Renal disorder is associated with prolonged stays in intensive care unit and hospital, morbidity and mortality. Aim of this study is specific evaluation of association between preoperative creatinine [Cr] with atrial fibrillation [AF] after elective off-pump CABG in non-diabetic male patients with normal ejection fraction. Two hundred non-diabetic male patients with normal ejection fraction undergoing elective off pump CABG surgery enrolled in this cross-sectional study and were stratified by present or absence of postoperative atrial fibrillation patients with postoperative new-onset atrial fibrillation [n=100] as group 1 and patients without new-onset postoperative atrial fibrillation as group 2 [n=100]. Preoperative serological test of the participants, such as serum creatinine, were recorded in their medical dossiers. Data were analyzed in SPSS-16 software and tested for association between atrial fibrillation with creatinine level by using student t test, chi-square test or logistic regression. Cr level in patients with and without AF three days before surgery were 1.8 +/- 0.3 and 1.0 +/- 0.4 respectively [P value for Cr=0.00]. On surgical day, mean Cr level in patients with and without AF were 1.6 +/- 0.2 and 1.1 +/- 0.5 respectively [P value for Cr = 0.00]. Of the 100, male patients with postoperative AF, duration and frequency of recurrence of AF were not associated with Cr at three days before surgery and on surgical days [P>0.05]. Patients with postoperative AF had unsuitable status of renal function compare to patients without AF; however, preoperative serum creatinine cannot associate with duration and frequency of recurrence of AF