Optimized antimicrobial peptide [Bacitracin] production by immobilized and free cells and of bacillus Spp GU215 using wood chips and silicon polymer beads
Pakistan Journal of Pharmaceutical Sciences. 2013; 26 (6): 1077-1082
em Inglês
| IMEMR
| ID: emr-148534
ABSTRACT
The immobilization of bacillus spp. GU215 on silicon polymer beads, wood chips was performed and antibiotic peptide [bacitracin] production, optimization of parameters were investigated. The immobilized cells presented elevated levels of activity than free cells. The silicon polymer based cells showed widest zones of inhibitions [18mm] in 72 hours and 4% concentration of glucose, PH 8 and 30°C, whereas a marginal decrease in the activity [14mm] was noticed in case of wood chips based immobilization systems and least stable immobilization in 72 hours incubation time, 4% glucose concentration, PH 8 and 30°C. This study illustrates that the silicon polymer based beads facilitate a strong interactions with bacitracin producing cells and render them suitable for excessive and long time production of antibiotic
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Polímeros
/
Silício
/
Bacillus
/
Madeira
/
Células Imobilizadas
Idioma:
Inglês
Revista:
Pak. J. Pharm. Sci.
Ano de publicação:
2013
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