Comparison of letrozole and clomiphene citrate efficacy along with gonadotrophins in controlled ovarian hyperstimulation for intrauterine insemination cycles
Journal of Reproduction and Infertility. 2013; 14 (3): 138-142
em Inglês
| IMEMR
| ID: emr-148678
ABSTRACT
We performed this study to investigate and compare the effects of Letrozole and gonadotrophins versus Clomiphene Citrate and gonadotrophins in women undergoing superovulation for Intrauterine Insemination [IUI]. We performed this prospective cohort study at Australian Concept and Fertility centre, Karachi Pakistan. Women younger than 40 years of age with patent fallopian tubes and infertility of more than 2 years in duration who were undergoing IUI and gonadotrophins therapy were divided into two groups, one received Letrozole for 5 days and another received Clomiphene Citrate for 5 days. All 500 IUI treatment cycles conducted from March 2008 to March 2010 were included. Patients co-treated with Letrozole required fewer gonadotrophins administrations [median difference, 300 IU [95% confidence interval [CI], 225-375 IU], developed more follicles larger than 14 mm [median difference, 1 follicle, 95% CI, 1-2 follicles], and had a thicker endometrium [median difference, 1 mm, 95% CI, 0.4-1.6 mm]. The pregnancy rate was not significantly different between two groups [11% vs. 12.6%]. The addition of Letrozole to gonadotrophins decreases gonadotrophins requirements and improves endometrial thickness, without a significant effect on pregnancy rates. An improved pregnancy rate has been observed in older age group, >35 years with Letrozole
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Triazóis
/
Gravidez
/
Estudos Prospectivos
/
Estudos de Coortes
/
Clomifeno
/
Gonadotropinas
/
Infertilidade
/
Inseminação
/
Nitrilas
Tipo de estudo:
Estudo de incidência
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
J. Reprod. Infertil.
Ano de publicação:
2013
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