Effect of period-suppressing danazol therapy on the endocrine profile of pretreatment normally menstruating women

ABSTRACT

A dose of 400 mg danazol daily for 6 months produced no persistent change in basal levels of serum gonadotrophins. Nevertheless there was an enhanced luteinizing hormone response to exogenous luteinizing hormone releasing hormone. Both oestradiol and sex hormone binding globulin showed a significant secondary rise after an initial marked drop. Prolactin followed the oestradiol trend but dehydroepiandrosterone sulphate showed no significant 'between months' change throughout the study