[Genetic association of selected microsatellite with some metabolic syndrome components in Iranian Fars and Azari families]

ABSTRACT

Family base association test [FBAT] is widely used in study of genetic association of allele of genetic markers and different phenotype for locating genes locus. The present study attempted to investigate the genetic association of some candidate microsatellites with HDL-C, triglyceride, and waist in order to find chromosomal area locus of effective genes in metabolic syndromes in Persian and Azari people of Iran. in this study 107 families were selected from participants in Tehran Lipid and Glucose Study. Each family had at least one member with metabolic syndrome [according to ATP III] and at least two members with reduced HDL-C level. The genetic association of HDL-C, triglyceride, and waist with some candidate microsatellites in chromosome 8, 11, 12, and 16 was studied using FBAT. the data covered 107 families consisting of 483 individuals. For Persian individuals, study of Chromosome 8 revealed significant association between D8S514 and HDL-C and between D8S1743 and triglyceride [P<0.05]. For Azari individuals, association of D8S1132 and D8S1743 in Chromosome 8 to HDL-C was significant [P<0.05]. FBAT is robust against confounders such as misspecification of genetic models and population stratification. By finding microsatellites affecting HDL-C, triglyceride, and waist, the results found in this study may be helpful in determining predisposing genes in metabolic syndrome.