[ comparison of the relationship between the serum level of vitamin D and coronary artery disease in patients with type 2 diabetes]

ABSTRACT

Cardiovascular diseases are among the most common causes of death and disability in patients with type 2 diabetes. According to some studies, Vitamin D deficiency is associated with risk of type 2 diabetes and cardiovascular diseases. The aim of this study was to compare the serum level of Vitamin D between diabetic patients with coronary artery diseases and control group. In this case-control study, patients with diabetes referred to Shahid Beheshti Hospital of Qom for coronary angiography, were divided into two groups of positive angiography [case group] and negative angiography [control group]. In this study, stenosis of the lumen of at least one coronary artery more than 50% was considered as positive angiography and suffering from coronary artery disease, and stenosis lower than 50% was considered as negative angiography. Personal characteristics, biographical information, consisting of age, gender, history of hypertension, hyperlipidemia, smoking, history of coronary artery disease, and family history were recorded using a questionnaire. Venous blood samples of the patients were taken to measure the serum level of 25-hydroxy Vitamin D, and the two groups were compared in terms of Vitamin D level. The mean serum level of 25-hydroxy Vitamin D was 35.09 +/- 26.41ng/ml. Also, there was no significant difference between case and control groups. The level was 35.67 +/- 29.58ng/ml in the case group and 34.50 +/- 23.30ng/ml in control group. The level of Vitamin D in patients with cardiac disease had no significant difference. The results of this study indicated that there was no relationship between serum level of 25-hydroxy Vitamin D in type 2 diabetic patients and stenosis of coronary arteries