New insights into VEGF-A alternative splicing: key regulatory switching in the pathological process
AJMB-Avicenna Journal of Medical Biotechnology. 2014; 6 (4): 192-199
em Inglês
| IMEMR
| ID: emr-149832
ABSTRACT
Vascular endothelial growth factor [VEGF-A] is one of the most important regulatory factors in pathological and physiological angiogenesis. Alternative splicing is a complicated molecular process in VEGF-A gene expression which adds complexity to VEGF-A biology. Among all VEGF-A exons, alternative splicing of exon 8 is the key determinant of isoform switching from pro-angiogenic VEGF-xxx to anti-angiogenic VEGF-xxxb. This is known as a key molecular switching in many pathological situations. In fact, the balance between VEGF-xxx and VEGF-xxxb isoforms is a critical controlling switch in both conditions of health and disease. Here, the properties of VEGF-xxx and VEGF-xxxb isoforms were discussed and their regulatory mechanism and their roles in certain pathological processes were evaluated. In summary, it was suggested that C-terminal VEGF-A alternative splicing can provide a new treatment opportunity in angiogenic diseases
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Expressão Gênica
/
Processamento Alternativo
/
Inibidores da Angiogênese
/
Neovascularização Patológica
Idioma:
Inglês
Revista:
Avicenna J. Med. Biotechnol.
Ano de publicação:
2014
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