[Genetic instability and centrosome abnormality in cancer]

ABSTRACT

Genetic instability is an important issue in cancer and including two important types of chromosome instability and microsatellite instability. Centrosome abnormality is a leading cause of chromosome instability. Centrosome plays as a microtubule organizing center [MTOC] to determine number, polarity and organization of interphase and metaphase microtubule. Centrosomes take part in cytoplasm organization, cell polarity and chromosome distribution to daughter cells. Numbers and function of centrosomes are regulated by genetic factors and polar mitotic apparatus. Cancer cells display a wide range of centrosome abnormality in in vitro and in vivo. Together, in this article we review recent and basic concepts of centrosome abnormality in cancer cells