[Correlation between assymetric dimethyl arginine [ADMA] and coronary atherosclerosis and severity of coronary artery stenosis]

ABSTRACT

Cardiovascular diseases are among important causes of mortality and it is essential to identify different factors that are associated with it. One of the factors that have been studied in recent years is asymmetric dimethylarginine [ADMA]. The aim of this study was to measure ADMA in atherosclerotic patients and to compare it with controls. In a case-control study, 70 patients with documented coronary stenosis, and 70 controls, without coronary disease, were chosen. Patients and controls aged between 40 and 70 years, and were of both genders. The serum level of ADMA was measured, using Cusabio Brand ELISA Kits, Wuhan Huamei Biotech, Inc, China. Analysis of data were done by ANOVA and T Test. The data were collected from 70 patients, and 70 matched controls. The mean level of serum ADMA in patients was 94.7 +/- 37 ng/ml while it was 51.5 +/- 33.6 ng/ml in controls; this difference was statistically significant [P<0.001]. The mean level of ADMA in patient with mild, moderate and severe stenosis, were 55.6 +/- 3.3, 79.5 +/- 9.2 and 108.9 +/- 35.7 ng/ml, respectively; the difference among these groups were statistically significant [P<0.001]. Data of this study showed that there was significant correlation between ADMA and atherosclerosis. In addition, there was a significant correlation between ADMA serum level and severity of coronary artery stenosis