Your browser doesn't support javascript.
loading
Meta-analysis of selective serotonin reuptake inhibitors [SSRIs] compared to tricyclic antidepressants [TCAs] in the efficacy and safety of anti-depression therapy in Parkinson's disease[PD] patients
IJPR-Iranian Journal of Pharmaceutical Research. 2014; 13 (4): 1213-1219
em Inglês | IMEMR | ID: emr-151739
ABSTRACT
To assess the efficacy and safety of selective serotonin reuptake inhibitors[SSRIs] and tricyclic antidepressants[TCAs] in treatment of Parkinsonian depression. A computer-based search was conducted in the databases of PUBMED, MEDLINE, EMBASE and CochraneControlled Trails Register up to December 2011. The random controlled clinic trials about SSRIs and TCAs in treatment of Parkinsonian depression were collected. Statistical analysis was completed using Review Manager, version 5.0. Five clinic controlled trials were identified for this meta-analysis. There was no significant statistical difference in the response rate of treatment [RR 0.95, 95%CI [0.78, 1.16]] and Hamilton depression score [RR -2.54, 95%CI [-5.35, 0.26]] between two groups. In term of complications, no statistical difference was observed in the insomnia rate between two groups [RR 0.82, 95%CI [0.24, 2.84]]. Moreover, the incidence rate of xerostomia [RR 0.21, 95%CI [0.07, 0.65]] and constipation [RR 0.12, 95%CI[0.02, 0.63]] was lower in SSRIs group rather than those in TCAs group. In general, SSRIs and TCAs have comparable efficacy and equal acceptability in treatment of Parkinson's disease-induced depression. However, SSRIs are superior to TCAs in the terms of xerostomia and constipation
Buscar no Google
Índice: IMEMR (Mediterrâneo Oriental) Tipo de estudo: Ensaio Clínico Controlado Idioma: Inglês Revista: Iran. J. Pharm. Res. Ano de publicação: 2014

Similares

MEDLINE

...
LILACS

LIS

Buscar no Google
Índice: IMEMR (Mediterrâneo Oriental) Tipo de estudo: Ensaio Clínico Controlado Idioma: Inglês Revista: Iran. J. Pharm. Res. Ano de publicação: 2014