Assessment of metabolic derangements in diabetes and associated hyperglycemic emergencies

ABSTRACT

To assess and compare the plasma insulin level and pre-treatment metabolic and acid base status findings in patients with uncontrolled TIDM, uncontrolled T2DM, DKA and HHS with healthy non-diabetic subjects. A retrospective analytical study. This study was conducted at the Army Medical College, Rawalpindi during the period from 2004 to 2006. This study was conducted on TIDM, T2DM, DKA and HHS patients and monitored insulin level, plasma osmolatily, serum electrolytes and arterial blood gases levels revealed that the clinical records and data confirmed and described each event and its likely causes. Ketoacidosis was frequently seen among persons with type 1 diabetes with marked hypoinsulinemia, hyperkalemia and acidosis. Hyperinsulinemia, acidosis and hyperosmolality were the significant finding in HHS. The observed association between insulin level and pretreatment metabolic and acid based derangements were statistically highly significant