Potency of aqueous white grubs extract against CCI[4] induced liver diseases in rats

ABSTRACT

The potency of aqueous white grubs extract was assessed in the cure of carbon tetrachloride [CCI[4]] - induced lipoperoxidation in rats. The three different dosages were administered [1 g/kg, 2 g/kg and 8 g/kg] daily to different groups of rats for up to 9 days after inducing lipoperoxidation using CCI[4] at a dose of 120 mg/kg the serum aspartate aminotransferase [AST], alanine aminotransferase [ALT], and alkaline phosphatase [ALP] activities as well as levels of serum malondialdehyde [MDA], total protein [TP] and albumin [ALB] of the rats after 9 days of white grubs extract administration were found to be similar to those of control rats [not CCI[4] - treated]. This shows possible curative effects of the white grubs extract, which were found to be dependent on both factors, viz. the dose administered and the duration of treatment