Acta Medica Iranica. 2012; 50 (10): 664-669
em Inglês
| IMEMR
| ID: emr-152031
ABSTRACT
We compared the extent of temporary threshold shift [TTS] and hair cell loss following high level 4 kHz noise exposure with those preconditioned with moderate level 1 and 4 kHz octave band noise. Fifteen Male albino guinea pigs [300- 350 g in weight] were randomly allocated into three groups those exposed to 4 kHz octave band noise at 102 dB SPL [group 1, n=5]; those conditioned with 1 kHz octave band noise at 85 dB SPL, 6 hours per day for 5 days, then exposed to noise [group 2, n=5]; those conditioned with 4 kHz octave band noise at 85 dB SPL, then exposed to noise [group 3, n=5]. An hour and one week after noise exposure, threshold shifts were evaluated by auditory-evoked brainstem response [ABR] and then animals were euthanized for histological evaluation. We found that TTS and cochlear damage caused by noise exposure were significantly reduced by 1 kHz and 4 kHz conditioning [P<0.001]. We also showed that 4 kHz protocol attenuates noise- induced TTS but no significant TTS reduction occurred by 1 kHz conditioning. Both protocol protected noise-induced cochlear damage. We concluded that lower tone conditioning could not protect against higher tone temporary noise-induced hearing loss, thus conditioning is a local acting and frequency-dependent phenomenon
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Índice:
IMEMR (Mediterrâneo Oriental)
Idioma:
Inglês
Revista:
Acta Med. Iran.
Ano de publicação:
2012
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