Relationship of adiponectin level with glycemic status and lipid profile in type 2 diabetic men

ABSTRACT

To determine serum adiponectin level, glycemic status and lipid profile in type 2 diabetic men belonging to Khyber Pakhtunkwa [KPK], and to find any possible relationship between them. Thirty six healthy adult males and thirty six type 2 diabetic males were randomly selected in a cross - sectional study. After an overnight fasting their blood samples were taken and analyzed for serum adiponectin, glycosylated hemoglobin [HbA[1]c], fasting blood glucose [FBG] and lipid profile including total cholesterol [TC], triglycerides [TG], low - density lipoprotein cholesterol [LDL - C], high - density lipoprotein cholesterol [HDL - C] and very low lipoprotein cholesterol [VLDL - C]. Type 2 diabetic males when compared to healthy males showed significantly low levels of serum adiponectin [3.2 +/- 1.3 vs. 11.06 +/- 2.5, P = 0.01] and HDL - C [32.4 +/- 9.6 vs. 42.4 +/- 8.6, p Serum adiponectin level showed a significant negative correlation with FBG [r - 0.596; p men. Adiponectin also showed a significant positive association with HDL - C in controls [r - 0.948; p type 2 diabetes [r - 0.860; p Conclusion: Serum adiponectin level is markedly decreased in type 2 diabetic cases. Moreover, it is associated positively with HDL - C and negatively with HbA[1]c and TG levels. Hypoadiponectinaemia is associated with deranged glycaemic status and lipid profile in men having type 2 diabetes mellitus