Horsetail mixture on rheumatoid arthritis and its regulation on TNF- alpha and IL-10

ABSTRACT

Taking autoimmune inflammation of rheumatoid arthritis as entry point, this paper discussed the clinical effect of horsetail mixture on rheumatoid arthritis [RA] and its mechanism. A total of 60 cases of patients with RA were randomly divided into experimental group and control group using randomized controlled trial. We observed its biochemistry, TNF- alpha and IL-10 before and after treatment, and then systematically assessed the clinical effect of horsetail on RA. Results showed that the total effective rate of experimental group was 80%, while that of control group was 16.67%. After statistical treatment, the differences between two groups were significant [p>0.05]. Comparison of the difference value of TNF-alpha [p<0.05] and IL-0.05 in serum between groups before and after treatment, there were significant differences. Comparison of CRP within group before and after treatment was significant different [p<0.05], while comparison of CRP between groups was not significantly different [p<0.05]. Comparison of ESR and RF within group before and after treatment was significantly different [p<0.01], and comparison of them between groups was also significantly different [p<0.05]. Comparison of difference values within group before and after treatment were also significantly different [p<0.01]. It was concluded that horsetail mixture has remarkable curative effect on rheumatoid arthritis, and its clinical application is safe and reliable. It has obvious down regulatory effect on cell factor TNF- alpha related to RA, that is, it can down regulate the level of pre-inflammatory factor TNF- alpha as well as the level of anti-inflammatory factor IL-10. Therefore, it is considered that the regulating effect of horsetail mixture on TNF- alpha and IL-10 is one of the mechanisms of its treatment on RA