Tumour induced osteomalacia
JPMA-Journal of Pakistan Medical Association. 2015; 65 (2): 220-222
em Inglês
| IMEMR
| ID: emr-153769
ABSTRACT
Tumour-induced osteomalacia [TIO] is a rare paraneoplastic syndrome usually presenting with bone pain, fracture of bones and muscle weakness. It is caused by high serum levels of fibroblast growth factor 23 [FGF-23], which is a hormone-regulating phosphate, and vitamin D. FGF-23 is secreted by several tumours, especially benign mesenchymal tumours which are very small and difficult to locate. There is a significant delay from onset of symptoms to the diagnosis of this entity due to occult nature of this disease. We present a case of young male who presented with long history of progressively worsening muscular pain and weakness, rendering the patient confined to bed. Our aim of presenting this patient as a case report is to make physicians realise that any patient with unexplained muscular weakness and pain must undergo workup for TIO, including serum phosphate measurement, as this is a rare but potentially curable disease
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Dor
/
Síndromes Paraneoplásicas
/
Fosfatos
/
Debilidade Muscular
/
Fatores de Crescimento de Fibroblastos
/
Neoplasias
Tipo de estudo:
Relato de Casos
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
J. Pak. Med. Assoc.
Ano de publicação:
2015
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