Two novel pyrazoles derivatives with penicillamine-like activities

The antidotal activities of two positional isomers of dimethyl 1 H-pyrazole carboxylic acid derivatives [GI and GII] were evaluated against copper sulphate [CuSO4] in rats. The antiinflammatory properties of these compounds were determined in rats by the trypan blue method. Penicillamine was used in these experiments as a reference drug for comparative purposes. Median lethal doses [LD 50] of compounds in question were determined in mice. In addition, some pharmacological tests were carried out on the compounds. Results of these studies revealed that both the two compounds exhibited antidotal and anti-inflammatory effectiveness superior than those of penicillamine. Intraperitoneal injection of these compounds did not lead to any remarkable changes in the blood pressure, ECG or respiration of rabbits