Hepato-protective effect of ascorbic acid on oxidative stress in mice exposed to cypermethrin

ABSTRACT

To evaluate protective effect of ascorbic acid on liver parameters in mice exposed to Cypermethrin. Laboratory based randomized control trial. Research was conducted in Army Medical College's biochemistry and molecular biology department in association with department of pathology, Army Medical College, Rawalpindi and National Institute of Health, Islamabad, Pakistan from 19 May 2013 to 17 June 2013. Thirty albino mice of Balb/C strain weighing 40-45 g were randomly divided into three groups. Each group comprised 10 mice. Control group A which received normal diet. Cypermethrin experimental group B received Cypermethrin with normal diet experimental group C which received Cypermethrin and vitamin C with normal diet. This process continued for 28 days. After this duration serum alanine aminotransferase [ALT] and serum aspartate aminotransferase [AST] values were determined. Serum ALT and AST levels were significantly increased in group B as compared to group A [p < 0.001]. ALT levels of group A and group C were insignificant [p = 0.473]. AST levels of group A and C were significantly different [p < 0.01]. Ascorbic acid can protect liver from Cypermethrin induced oxidative stress in mice