Preparation and characterization of rifampin loaded mesoporous silica nanoparticles as a potential system for pulmonary drug delivery
IJPR-Iranian Journal of Pharmaceutical Research. 2015; 14 (1): 27-34
em Inglês
| IMEMR
| ID: emr-154864
ABSTRACT
The goal of this research is to determine the feasibility of loading rifampin into mesoporous silica nanoparticles. Rifampin was selected as a model lipophilic molecule since it is a well-documented and much used anti tuberculosis drug. The mesoporous silica nanoparticles were prepared by using tetraethyl ortho silicate and cetyltrimethyl ammonium bromide [as surfactant]. The prepared nanoparticles were characterized in terms of their particle size measurement and porosimetry. The results showed that the particle size is 218 +/- 46 nm [mean +/- SD] and surface area is 816 m[2]g[-1]. In order to load rifampin within the mesopores, adsorption experiments using three different solvents [methanol, water and dimethyl sulfoxide] were carried out. The loading procedure resulted in a significant improvement in the amount of rifampin loaded into mesoporous silica nanoparticles and methanol was found to be a suitable solvent, providing a drug entrapment efficiency of 52 %. Rifampin loaded nanoparticles underwent different in-vitro tests including, SEM and drug release. The in-vitro drug release was investigated using buffer phosphate [pH=7.4]. Regarding the drug release study, a biphasic pattern of release was observed. The drug-loaded mesoporous silica nanoparticles were capable of releasing 95% of their drug content after 24 h, following a faster release in the first four hours. The prepared rifampin loaded nanoparticles seem to have potential for use as a pulmonary drug delivery
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Silanos
/
Compostos de Cetrimônio
/
Sistemas de Liberação de Medicamentos
/
Dióxido de Silício
/
Nanopartículas
/
Pulmão
Idioma:
Inglês
Revista:
Iran. J. Pharm. Res.
Ano de publicação:
2015
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