Expression of p27 protein in oral and esophageal squamous cell carcinoma

ABSTRACT

Squamous cell carcinoma [SCC] is the most common malignant tumor of oral cavity [O] and esophagus [E]. P27 protein has a significant role in biological behavior of the tumors. The purpose of this study was to determine the frequency of P27 expression in OSCC and ESCC. Forty paraffin embedded blocks of OSCC and ESCC were collected and clinic pathological data were recorded in this descriptive study. Immunohistochemical staining [IHC] was done for P27 [Kipl] and Labeling Index [percent of positive cells in 10HPF] was calculated and then cases classified in to low [LI<25%] and high [LI>25%] expressions. Statistical analysis was performed by SPSS 16 using Fisher's exact and Mann-Whitney tests. Twenty-four cases [60%] were male and 16 cases [40%] were female. The mean age was 65.3+14.3. Twenty five percent of ESCCs and 10% of OSCCs showed high expression of P27. Seventy five percent of ESCC and 90% off OSCC showed low expression and there was no significant difference among OSCCs and ESCCs [P>0.05]. There were no significant correlations between age, sex, grade or size of the tumors and P27 expression in OSCCs and ESCCs. Low expression of P27 was found in most of ESCC and OSCC cases