comparative study of different brands of cetirizine hydrochloride tablets available in Karachi, Pakistan

ABSTRACT

The development of a formulation requires expertise during each manufacturing stage. Tablets are the most commonly used oral, solid dosage forms in which various excipients are used and various methods are employed for their preparation. Quality of tablets should fulfill certain specifications. If the formulations are not manufactured properly and are not optimized, they will not render the desired effects. This study shows the analysis and evaluation of various pharmaceutical parameters, i.e. thickness, hardness, weight variation, disintegration and dissolution, on different brands of cetirizine hydrochloride tablets available in the local market. Cetirizine hydrochloride is an orally administered drug used as anti-histaminic with almost no sedation. The analysis done can conveniently give a general survey of different brands of cetirizine hydrochloride tablets where the difference in parameters tested can relate to difference in the bioavailability of drugs