Role of latanoprost in the treatment of primary open angle glaucoma

ABSTRACT

The aim of this study was to observe the effect of Latanoprost in lowering intraocular pressure [IOP] in primary open angle glaucoma [POAG] patients. Prospective, open- label, Observational Study. This study was conducted at the Department of Pharmacology and Therapeutics, Basic Medical Sciences Institute, Jinnah Post-graduate Medical Centre, Karachi from February 2008 to July 2008. Thirty patients of POAG were enrolled and were treated with Latanoprost 0.005% eye drops for 12 weeks. The parameter examined was IOP by using Goldmann applanation tonometer. The results have been expressed as mean +/- SEM. The mean IOP of both eyes decreased significantly [from 27.16 +/- 0.19 mmHg to 17.94 +/- 0.23 mmHg; p<0.001]. The average percentage reduction in IOP was -33.94% from week 0 to week 12. Latanoprost 0.005% eye drops may become an important choice as a monotherapy for primary open angle glaucoma patients