[Prognostic value of markers of aggressiveness of urinary bladder tumours evaluated by immunohistochemistry]

ABSTRACT

Study the expression of the following immunohistochemical markers in Tumours of the bladder Proliferating Cell Nuclear Antigen [PCNA], Ki67 antigen [MIB1], the C-erbB2 proto- antigene, the tumor suppressor gene p53, the receptor for epidermal growth factor [EGF-R], the apoptosis suppressor gene bcl2, the carcinoembryonic antigen [CEA] and epithelial membrane antigen [EMA]. Study of retrospective series of 30 patients having tumours of the urinary bladder. The expression of PCNA with a cut-off value of 14% is correlated with recurrence [P = 0.010]. The expression of PCNA with a cut-off value of 1% is correlated with tumour stage [P = 0.003]. The expression of MIB1 with a cut-off value of 47% is correlated with recurrence [P = 0.010]. The expression of MIB1 with a cut-off value of 47% is correlated with the tumour progression in stage and/or in grade [P = 0.007]. The expression of C-erbB2 with a cutoff value of 28% is correlated in the tumour grade [P = 0.007]. The other antibodies didn't demonstrate a prognostic value. MIb1 and PCNA being correlated with recurrence, they can be useful with the decision of the rhythm of the endoscopy. The correlation of C-erbB2 with the tumour grade could serve to better graduating bladder tumours