Cellular immune response in acute hepatitis B leading to chronic carrier state
EMHJ-Eastern Mediterranean Health Journal. 1997; 3 (2): 322-335
em Inglês
| IMEMR
| ID: emr-156472
ABSTRACT
Immunological studies among jaundiced patients revealed significant changes in T-helper and T-suppressor cells among chronic HBV cases from the acute and control groups. The chronic cases revealed a highly significant decrease in interleukin-2R expression but their low interferon-gamma values were statistically nonsignificant from the control group. The acute cases recorded the highest interleukin-2R and interferon-gamma values. Lymphocyte blastogenesis assay in response to different mitogens and antigens produced two groups responders [acute cases] and nonresponders [chronic cases]. The responders revealed more intact specific and nonspecific cellular immune responses. Neither group differed with regard to their proliferative response to HBsAg, but vigorous response to HBcAg was a significant feature of the responders
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Linfócitos T
/
Portador Sadio
/
Incidência
/
Fatores de Risco
/
Interferons
/
Interleucina-2
/
Imunidade Celular
/
Testes de Função Hepática
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo de incidência
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
East Mediterr Health J.
Ano de publicação:
1997
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