Molecular studies on Yemeni sickle-cell-disease patients: Xmn I polymorphism
EMHJ-Eastern Mediterranean Health Journal. 1999; 5 (6): 1183-1187
em Inglês
| IMEMR
| ID: emr-156715
ABSTRACT
Our studies of the Saudi population have shown that in patients with mild presentation of sickle-cell disease [SCD] from Saudi Arabia's eastern region, the prevalence of polymorphic sites is high. However, the prevalence is very low in patients with severe SCD from the south-west of the country. We expanded these studies to a group of Yemeni patients with severe SCD, resident in Riyadh. We investigated a total of 60 chromosomes carrying the sickle-cell [Hb S] gene and 14 chromosomes carrying the Hb A gene. Amongst the Hb AA group, the prevalence was 42.9% and 57.1% for the presence [+] and absence [-] of Xmn I polymorphic sites. In the Hb SS individuals, the prevalence of Xmn I polymorphic sites was similar to the prevalence reported in the south-western region of Saudi Arabia
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Polimorfismo Genético
/
Índice de Gravidade de Doença
/
Globinas
/
Hemoglobina A
/
Hemoglobina Falciforme
/
Desoxirribonucleases de Sítio Específico do Tipo II
/
Estudos de Casos e Controles
/
Contagem de Eritrócitos
/
Índices de Eritrócitos
Limite:
Adolescente
/
Criança
/
Humanos
Idioma:
Inglês
Revista:
East Mediterr Health J.
Ano de publicação:
1999
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