Changes in B-glucuronidase and complement C3 under anesthesia in schistosomal and non-schistosomal patients

ABSTRACT

The effect of single halothane or nitrous oxide anaesthesia on complement C[3] and B-glucuronidase enzyme [B.G.] was studied in 30 patients divided into 3 groups each of 10. Group I and II received nitrous oxide 70% in o[2] and group III received halothane 1-1.5%. Group I were schistosomal patients, while the other two were non-schistosomal. Estimation of C[3], B.G. and liver function tests were performed pre-operatively, post-operatively [50-60 minutes of anaesthesia] and 4th post-operative day. It was observed that schistosomiasis causes significant increase in B.G. and decrease in C[3] Post-operative samples showed significant reduction ll C- and increase in B.G. p [P <0.001] in all groups. Se percent of depression was more significant in schistosomal group than non schistosomal group under nitrous oxide. Also the percent of depression was more significant under halothane than dtrous oxide in control groups. By the 4th day, there was sigtificant increase in both C-levet and B.G. activity [P<0.001] in all groups. No significant changes were detected in [%] changes B.G. except between schistosomal and non schistosomal patients [p[2]<0.001] under nitrous oxide. Liver function tests demonstrated significant changes in some pa-mieters in schistosomal patients only. This indicates that schis-sosoniiasis, anaesthesia and surgery arc established causes of tress, inducing alterations in C[3] and B.G. which are sensitive indicators of tissue injury and liver insult than routine liver tests