[Palmatine hydrochloride improves motor dysfunction in streptozotocin-induced diabetic rats]
Journal of Gorgan University of Medical Sciences. 2014; 16 (1): 42-48
em Persa
| IMEMR
| ID: emr-157572
ABSTRACT
Diabetes induces motor dysfunctions, Palmatine is an isoquinoline alkaloid, with anti-diabetic and antioxidant activities. This study was conducted to evaluate the effect of Palmatine on motor dysfunction in STZ-induced diabetic rats. In this experimental study, 32 male wistar rats were randomly allocated into control, Palmatine-treated non-diabetic, diabetic and Palmatine-treated diabetic groups. Diabetes was induced by STZ administration at the dose of 55 mg/kg/bw, intraperitoneally. Palmatine hydrochloride was administered subcutaneous at doses of 10 mg/kg/bw per day for a period of 6 weeks, one week after induction of diabetes. Blood glucose level was measured 1, 3, 5, 7 weeks after STZ injection. Locomotor activity tests including Y maze, grip-traction and inclined plane tests were performed to determining locomotor activity. In Y maze test, the number of arms entered significantly increased in Palmatine-treated diabetic group compared to diabetic group [P<0.05]. Grip traction and inclined plane tests significantly increased in Palmatine-treated diabetic group compared to diabetics animals [P<0.05]. Palmatine hydrochloride administration for 6 weeks improves motor dysfunctions in streptozotocin-induced diabetic rats
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Ratos Wistar
/
Força da Mão
/
Transtornos Neurológicos da Marcha
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Complicações do Diabetes
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Diabetes Mellitus Experimental
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Atividade Motora
Limite:
Animais
Idioma:
Persa
Revista:
J. Gorgan Univ. Med. Sci.
Ano de publicação:
2014
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