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Clinicopathological study of cutaneous vasculitides
JPAD-Journal of Pakistan Association of Dermatologists. 2014; 24 (1): 8-14
em Inglês | IMEMR | ID: emr-157634
ABSTRACT
To study the different patterns of cutaneous vasculitides along with their underlying etiologic factors and to assess the clinicopathological correlation. A cross sectional study was conducted on 30 consecutive patients, histologically diagnosed as cutaneous vasculitis in the department of dermatology and venereology, BSMMU, Dhaka. All patients were subjected to a baseline workup consisting of complete hemogram, serum-creatinine levels, liver function tests, chest X-ray, urine [routine and microscopic] examination besides antistreptolysin O titer, antinuclear antibody assay, rheumatoid factor assay, antineutrophilic cytoplasmic antibodies and hepatitis B and C. Histopathological examination was done in all patients while immunofluorescence was done in 9 patients. Out of a total of 30 patients diagnosed histologically as cutaneous vasculitis, 22 were classified as cutaneous small vessel vasculitis [CSVV], 6 as Heinoch-Schonlein purpura, and one each as urticarial vasculitis, and Behcet's syndrome. Approximately 30% of the patients had a significant drug history, 23.3% were attributed to infection. No cause was found in 46.7% cases. Only 9 patients could undergo direct immunofluorescence [DIF], out of which 4 were positive for vasculitis. Cutaneous small vessel vasculitis was the commonest type of vaculitis presenting to the dermatology outpatient department. The workup of patients with cutaneous vasculitis includes detailed history, clinical examination and investigations to rule out multisystem involvement followed by skin biopsy and DIF at appropriate stage of evolution of lesions. Follow up of these patients is very essential as cutaneous manifestations may be the formc fruste of serious systemic involvement
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Índice: IMEMR (Mediterrâneo Oriental) Assunto principal: Vasculite por IgA / Fator Reumatoide / Anticorpos Antinucleares / Estudos Transversais / Vasculite Leucocitoclástica Cutânea / Doenças do Tecido Conjuntivo / Técnica Direta de Fluorescência para Anticorpo / Testes de Função Hepática Tipo de estudo: Estudo de prevalência Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: J. Pak. Assoc. Dermatol. Ano de publicação: 2014

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Índice: IMEMR (Mediterrâneo Oriental) Assunto principal: Vasculite por IgA / Fator Reumatoide / Anticorpos Antinucleares / Estudos Transversais / Vasculite Leucocitoclástica Cutânea / Doenças do Tecido Conjuntivo / Técnica Direta de Fluorescência para Anticorpo / Testes de Função Hepática Tipo de estudo: Estudo de prevalência Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: J. Pak. Assoc. Dermatol. Ano de publicação: 2014