Effect of interferon therapy on fatty acid saturation index in hepatitis C virus infection
EMHJ-Eastern Mediterranean Health Journal. 2001; 7 (4-5): 779-786
em Inglês
| IMEMR
| ID: emr-157995
ABSTRACT
The ratio of stearic to oleic acids, i.e. the fatty acid saturation index, in red blood cell membranes was assayed in 60 patients with chronic hepatitis C virus infection before and after interferon-alpha therapy. Results were compared with 20 healthy controls. Hepatitis C virus titre was also assayed before and after interferon-alpha therapy. Within 2-5 months following interferon-alpha therapy, a significant inverse correlation was observed between saturation index and hepatitis C virus load. We conclude that hepatitis C virus infection enhances the degree of desaturation of 18-carbon fatty acids and that interferon-alpha is involved in their metabolism by increasing the degree of saturation and subsequent decrease in membrane fluidity
Buscar no Google
Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Antivirais
/
Ácidos Esteáricos
/
Estearoil-CoA Dessaturase
/
Índice de Gravidade de Doença
/
Ácidos Oleicos
/
Biomarcadores
/
Estudos de Casos e Controles
/
Cromatografia
/
Carga Viral
/
Hepatite C Crônica
Limite:
Humanos
Idioma:
Inglês
Revista:
East Mediterr Health J.
Ano de publicação:
2001
Similares
MEDLINE
...
LILACS
LIS