Bone marrow transplantation in thalassaemia patients in Shiraz, Islamic Republic of Iran
EMHJ-Eastern Mediterranean Health Journal. 2001; 7 (4-5): 835-837
em Inglês
| IMEMR
| ID: emr-158003
ABSTRACT
We report the results of allogeneic bone marrow transplantation in 26 female and 37 male patients with beta-thalassaemia major [age range 2-17 years], performed at Namazi Hospital over the period 1992-99. In all cases, standard conditioning and immunosuppressive regimens were employed. Currently, 50 patients remain thalassaemia-free, 9 of whom have developed chronic graft-versus-host disease. There were 8 deaths among the 13 unsuccessful transplant cases 4 due to acute uncontrollable graft-versus-host disease, and 4 to non-transplant-related causes such as hypoglycaemia, hypersensitivity reactions and advanced disease. We conclude that allogeneic bone marrow transplantation is an effective therapy for the treatment of beta-thalassaemia major, particularly for patients classified as classes I and II
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Prednisolona
/
Pré-Escolar
/
Doença Crônica
/
Imunoglobulinas Intravenosas
/
Talassemia beta
/
Condicionamento Pré-Transplante
/
Rejeição de Enxerto
/
Hipoglicemia
/
Anti-Inflamatórios
Tipo de estudo:
Relato de Casos
Limite:
Adolescente
/
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
East Mediterr Health J.
Ano de publicação:
2001
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