Red cell glucose-6-phosphate dehydrogenase phenotypes in Iraq
EMHJ-Eastern Mediterranean Health Journal. 2002; 8 (1): 42-48
em Inglês
| IMEMR
| ID: emr-158038
ABSTRACT
We attempted to characterize biochemically glucose-6-phosphate dehydrogenase [G6PD] variants in Iraqi individuals. Thus 758 healthy Iraqi males aged 18-60 years were randomly selected and 46 [6.1%] were G6PD deficient. Although the predominant non-deficient G6PD phenotype was G6PD B [92.6%], G6PD A+ was found in polymorphic frequency [1.3%]. In the deficient group, 31 cases were fully characterized, including 17 cases with features consistent with G6PD Mediterranean variant, while 12 had other biochemical features and were labelled as non-Mediterranean variant. The remaining two deficient cases were characterized as G6PD A- variant. The presence of a significant number of non-Mediterranean variant was unexpected and may be related to the more heterogeneous background of the Iraqi people
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Fenótipo
/
Polimorfismo Genético
/
Estudos de Casos e Controles
/
Epidemiologia Molecular
/
Eletroforese em Acetato de Celulose
/
Eritrócitos
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Favismo
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Frequência do Gene
/
Glucosefosfato Desidrogenase
Limite:
Adolescente
/
Adulto
/
Humanos
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Masculino
Idioma:
Inglês
Revista:
East Mediterr Health J.
Ano de publicação:
2002
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