Prevalence of endocrine complications in beta-thalassaemia major in the Islamic Republic of Iran
EMHJ-Eastern Mediterranean Health Journal. 2003; 9 (1-2): 55-60
em Inglês
| IMEMR
| ID: emr-158135
ABSTRACT
To identify the prevalence of endocrine dysfunction in Iranians with beta-thalassaemia, we assessed thyroid, parathyroid, pancreatic and adrenal function in 150 beta-thalassaemic patients aged 10-22 years at the Paediatrics Unit, Shiraz University of Medical Sciences. Primary hypothyroidism was found in 6.0% of patients [mean age 14.6 +/- 1.9 years], hypoparathyroidism in 7.3% [14.5 +/- 3.2 years], type 1 diabetes mellitus in 7.3% [13.9 +/- 2.8 years] and adrenal insufficiency in 1 patient. The relatively high frequency of endocrine dysfunction found in our study may be a result of poor disease control and management in early life when irreversible tissue damage occurs due to iron overload. These findings reinforce the importance of regular follow-up of patients with beta-thalassaemia major for early detection and management of associated complications
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Transfusão de Sangue
/
Quelantes de Ferro
/
Insuficiência Adrenal
/
Assistência ao Convalescente
/
Desferroxamina
/
Ferritinas
/
Transtornos do Crescimento
/
Hipoparatireoidismo
Tipo de estudo:
Estudo de prevalência
/
Estudo de rastreamento
Limite:
Adolescente
/
Adulto
/
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
East Mediterr Health J.
Ano de publicação:
2003
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