Apolipoprotein B gene polymorphisms in people in the East Mediterranean area of Turkey
EMHJ-Eastern Mediterranean Health Journal. 2004; 10 (1-2): 125-130
em Inglês
| IMEMR
| ID: emr-158267
ABSTRACT
Point mutations in the receptor binding domain of low density lipoprotein may increase cholesterol levels in blood. Three mutations of Apo B-100 protein result in defective binding [Arg 3500 ----> [corrected] Gln, Arg 3500 ----> [corrected] Trp and Arg 3531 ----> [corrected] Cys]. We estimated the frequency of Apo B point mutations [codon 3500] C9774T [Arg 3500 ----> [corrected] Trp] and G9775A [Arg 3500 ----> [corrected] Gln] in 179 atherosclerotic, 145 hyperlipidaemic individuals and 272 healthy individuals in the east Mediterranean region of Turkey. Lipid and lipoprotein levels were measured with routine biochemical analyser and Apo B mutation was detected using real-time PCR. Neither mutation was found. In this region, Apo B-100 protein mutations are rare and causes of hyperlipidaemia and atherosclerosis may therefore be unrelated to them
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Apolipoproteínas A
/
Arteriosclerose
/
Estudos de Casos e Controles
/
Causalidade
/
Doenças Raras
/
Apolipoproteína B-100
/
Frequência do Gene
/
HDL-Colesterol
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
East Mediterr Health J.
Ano de publicação:
2004
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