Efficacy of sulfadoxine/pyrimethamine for uncomplicated Plasmodium falciparum malaria in a small sample of Sudanese children
EMHJ-Eastern Mediterranean Health Journal. 2004; 10 (3): 309-314
em Inglês
| IMEMR
| ID: emr-158288
ABSTRACT
A prospective clinical trial was carried out to determine in vivo efficacy of sulfadoxine/pyrimethamine for the treatment of uncomplicated Plasmodium falciparum malaria in children in New Halfa. Forty patients were enrolled; 31 completed the 28-day follow-up. Six [19.4%] patients showed recurrence of parasitaemia during follow-up, while the rest [80.6%] cleared the parasites and responded fully to treatment. All the failures were late treatment failures. Parasite genotyping showed that 1 [16.7%] of the 6 cases of late parasitaemia was due to reinfection while the rest [83.4%] were due to true recrudescence. During the follow-up period 22.6% of patients showed gametocytaemia. The high level of treatment failure as well as gametocytaemia necessitates the introduction of artesunate in this combination therapy
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Contagem de Ovos de Parasitas
/
Adolescente
/
Malária Falciparum
/
Doenças Endêmicas
/
Artemisininas
/
Combinação de Medicamentos
/
Genótipo
/
Animais
Limite:
Criança
/
Feminino
/
Humanos
/
Lactente
/
Masculino
Idioma:
Inglês
Revista:
East Mediterr Health J.
Ano de publicação:
2004
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