Low-dose quinine for treatment of chloroquine-resistant falciparum malaria in Sudanese pregnant women
EMHJ-Eastern Mediterranean Health Journal. 2004; 10 (4-5): 554-559
em Inglês
| IMEMR
| ID: emr-158320
ABSTRACT
Pregnant Sudanese women who presented at a hospital in eastern Sudan with chloroquine-resistant falciparum malaria were randomly allocated to one of two quinine regimens low-dose [10 mg/kg 2 times/day] [18 patients] or st and ard [10 mg/kg 3 times/day] [24 patients]. Treatment was for 7 days and follow-up for 28 days. Significantly fewer patients in the low-dose group reported vomiting and abdominal pain than the st and ard regimen group. Hypoglycaemia, preterm labour and recrudescence were slightly but not significantly higher in patients in the st and ard group than low-dose group. There were no significant differences between the groups in the mean time from admission to remission of fever and parasite clearance. We tentatively advocate the use of quinine 2 times/day to reduce side-effects and improve compliance
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Quinina
/
Resistência a Medicamentos
/
Esquema de Medicação
/
Cloroquina
/
Administração Oral
/
Idade Gestacional
/
Malária Falciparum
/
Febre
/
Hipoglicemia
Tipo de estudo:
Ensaio Clínico Controlado
Limite:
Adulto
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
East Mediterr Health J.
Ano de publicação:
2004
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