Clinico-pathological profile of acute promyelocytic leukaemia at Al-Amal oncology-haematology centre, Qatar
EMHJ-Eastern Mediterranean Health Journal. 2010; 16 (9): 958-965
em Inglês
| IMEMR
| ID: emr-158528
ABSTRACT
This cases series describes the profile of adult patients with acute promyelocytic leukaemia [APL] at a referral hospital in Qatar of 34 acute myeloid leukaemia [AML] cases diagnosed, 11 [32%] were classified as APL. Disseminated intravascular coagulation was common at presentation [91%]. Severe thrombocytopenia was seen in 73%, leukocytosis in 55% and severe anaemia in 45%. Only 2 patients were of the classic hypergranular type. In the remaining 9 patients, 3 morphological subtypes were recognized microgranular variant [6 patients], hyperbasophilic [2 patients] and regular nuclear outline M3r [1 patient]. Translocation t[15;17] was detected in 63% of cases. APL constitutes a high proportion of AML cases in Qatar, with considerable morphological heterogeneity and a predominance of APL variants with unfavourable presenting features
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Leucemia Promielocítica Aguda
/
Imunofenotipagem
/
Citogenética
Limite:
Adolescente
/
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
East Mediterr Health J.
Ano de publicação:
2010
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