Evaluation of specific biochemical indicators of Helicobactepylori-associated gastric cancer in Egypt
EMHJ-Eastern Mediterranean Health Journal. 2012; 18 (5): 501-507
em Inglês
| IMEMR
| ID: emr-158779
ABSTRACT
The aim of the study was to assess the accuracy of some specific biochemical indicators in discriminating between Helicobacter pylori-associated gastritis and H. pylori-associated stomach cancer [serum gastrin level, serum soluble E-cadherin and tissue COX-2 activity, as well as serodiagnostic markers for H. pylori infection] in order to find a simple diagnostic test that can reasonably predict the development of gastric cancer. The study participants comprised 20 patients with gastric carcinoma, 20 patients with positive H. pylori-associated gastritis and 20 individuals as the control group. Standard procedures and quality control measures were followed. Using cut-off values and ROC analysis to assess the diagnostic abilities of the biochemical indicators, E-cadherin showed the highest sensitivity [100%]. We suggest that close follow-up together with periodic endoscopic examination for all patients with persistent H. pylori infection and serum soluble E-cadherin level above 5 microg/mL is essential
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Neoplasias Gástricas
/
Gastrinas
/
Caderinas
/
Helicobacter pylori
/
Sensibilidade e Especificidade
/
Gastrite
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
East Mediterr Health J.
Ano de publicação:
2012
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