High prevalence of Klebsiella pneumoniae carbapenemase-mediated resistance in K. pneumoniae isolates from Egypt
EMHJ-Eastern Mediterranean Health Journal. 2013; 19 (11): 947-952
em Inglês
| IMEMR
| ID: emr-159123
ABSTRACT
The emergence and rapid spread of antibiotic-resistant Klebsiella pneumoniae isolates harbouring the bla[KPC] gene that encodes for carbapenemase production have complicated the management of patient infections. This study in a tertiary care hospital in Egypt used real-time PCR assay to test ertapenem-nonsusceptible isolates of K. pneumoniae for the presence of the bla[KPC] gene and compared the results with modified Hodge test. Antibiotic sensitivity was performed by standard methods, and interpreted following both the old CLSI breakpoints [M100-S19] for carbapenems and the revised breakpoints [M100-S22]. From the 45 non-duplicate isolates of K. pneumoniae recovered from different clinical specimens, a high prevalence of ertapenem-nonsusceptible isolates [44.4%] was reported using the new lower CLSI breakpoints. The bla[KPC] gene was confirmed in 14/20 [70.0%] of these isolates. The high prevalence of ertapenem nonsusceptibility at a tertiary care hospital in Egypt was predominantly attributed to K. pneumoniae carbapenemase-mediated resistance mechanisms in K. pneumoniae isolates
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Testes de Sensibilidade Microbiana
/
Carbapenêmicos
/
Reação em Cadeia da Polimerase
/
Estudos Prospectivos
/
Beta-Lactamas
/
Klebsiella pneumoniae
Tipo de estudo:
Estudo de prevalência
Idioma:
Inglês
Revista:
East Mediterr Health J.
Ano de publicação:
2013
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