Correlation study of [CMV] in the presence of [HCV] and/or [HBV] in hepatocellular carcinoma [HCC] patients

ABSTRACT

The involvement of CMV in hepatocellular carcinoma [HCC] is not totally defined till now. The aim of this work is to study the prevalence of CMV in HCC patients and its correlation to hepatitis B virus [HBV] and hepatitis C virus [HCV] related HCC carcinogenesis. Forty hepatic disease patients were involved 10 [25%] of them were Not suffering from HCC and 30 with HCC [75%] and its complications. Different investigations have been measured in serum of all patients concerned to liver complications. These measurements were HCV RNA and HBV DNA both using Real- Time PCR technique. CMV, AFP and ANA using ELISA technique. Finally SGOT and SGPT using conventional clinical analysis techniques. Concerning HCC +ve patients 73.4% of them were CMV -ve and 26.6% were CMV +ve, while 16.7% of them were HCV -ve and 83.3% were HCV +ve and 50% of them were HBV -ve and HBV +ve. Concerning HCC -ve patients 80% of them were CMV -ve and 20% were CMV +ve, while all were HCV -ve and HBV -ve. High AFP concentration was observed in 93.4% of HCC +ve patients. In conclusion both HBV and HCV and AFP were found to be highly specific risk factors in HCC patients [P< 0.0001], while CMV viral activities were not a risk factor to HCC patient [P< 0.673]