Twin pregnancy obtention of patient with nonmosaic klinefelter's syndrome and his wife with chromosome 9 inversion by ICSI treatment

ABSTRACT

A 24-year-old man was diagnosed with klinefelter's syndrome [KS] and his wife was found to have an inversion on chromosome 9-46, XX, inv [9] [p11q21]- because of infertility. Intracytoplasmic sperm injection [ICSI] was performed for fertilization after fluorescence in-situ hybridization [FISH] was used to analyze the aneuploidy rate of the X and Y chromosomes of the ejaculated sperms of the patient, and 99 sperms were haploid among 100 sperms that were to be analyzed. A twin pregnancy was achieved. The chromosomes of the two fetuses were identified as 46, XY and 46, XY, inv [9][p11q21] after a prenatal diagnosis at 18 weeks gestation. Two healthy twins were born through caesarean section at 32 weeks gestation because of premature rupture of membranes [PROM]