[ role of 5-HT[2A] and 5-HT[2c] receptors on harmaline-induced eating behavior in 24-h food-deprived broiler cockerels]

ABSTRACT

This study was designed to examine the effects of intracerebroventricular [ICV] injection of ketanserin [5-HT[2a] receptor antagonist] and SB242084 [5-HT[2c] receptor antagonist] on harmaline induced feeding and drinking response in 24-h food-deprived [FD24] broiler cockerels. At first, guide cannula was surgically implanted in the right lateral ventricle of chickens. In experiment 1, birds were injected intracerebroventriculary with 0, 25, 50 and 100 microg of harmaline. In experiment 2, chickens received 10 microg ketanserin prior to the injection of harmaline. In experiment 3, birds were administered with harmaline after 3 microg SB242084 and the cumulative food and water intake was determined at 3 h post injection. The results of this study showed that harmaline decreases food consumption and increases water intake in FD24 broiler cockerels [Pharmaline on food and water intake was significantly attenuated with ketanserin and SB242084 pretreatment [Pharmaline and 5-HT[via 5-HT[2a] and 5-HT[2c] receptors] on eating response in chicken