Effect of lorazepam on liver and spleen of pre-hatching chick embryos

ABSTRACT

Histopathological effects of Lorazepam were evaluated on liver and spleen of prehatching chick embryos. Injections were performed after 24-hours of incubation by three different experimental doses 0.001, 0.003 and 0.006 mg lorazepam/egg. The liver showed fine vacuolated hepatocytes with a very uniform homogeneous cytoplasm as well as swelling of cells fatty change, degenerative parenchymal cells and hepatic cells of the infiltrative type. Sections of spleen were represented by loss of regular pattern, vascular lesions and progressive depletion of white pulp