Hepatoprotective effect of garlic [allium sativum] and milk thistle [silymarin] in isoniazid induced hepatotoxicity in rats

ABSTRACT

Assessment and comparison of hepatoprotective role of garlic and silymarin in antituberculosis drug [Isoniazid] induced hepatotoxicity. Healthy rats weighing 150-200g were selected for the study. Rats were divided into four groups, i.e. group A [Control], group B [INH treated group], group C and D serve as experimental groups. The group A received only the normal diet, Group B along with normal diet received the isoniazid [50 mg/kg/day], Group C along with normal diet received the isoniazid [50 mg/kg/day] and Silymarin [200 mg/kg/day], and Group D along with normal diet received the isoniazid [50 mg/kg/day] and garlic [0.25 g/kg/day]. On completion of 28 days of treatment blood samples were collected for the assessment of liver function. In group B there was abnormal rise in the levels of biochemical markers [ALT, AST, ALP and Total Bilirubin]. In group C the biochemical markers were near normal levels and in group D the levels of biochemical markers were within normal limits. Both the garlic and silymarin have shown the hepatoprotective effect against the Antituberculosis drug [isoniazid] induced hepatotoxicity in experimental animal model