Mega-dose vitamin C: is it harmful to the liver? biochemical and histological study in rats
Jordan Journal of Pharmaceutical Sciences. 2012; 5 (1): 8-20
em Inglês
| IMEMR
| ID: emr-163080
ABSTRACT
To investigate if mega-doses of vitamin C would have deleterious effects on the liver in an animal model. A mega-dose of vitamin C [1000 mg/kg/day] was administered by oral gavage to male Wistar rats for 60 days. Both biochemical and histopathological measures were undertaken. The results showed that a mega-dose of vitamin C significantly elevated lipid peroxidation and transaminase activity level in addition to the significant suppression of antioxidant enzymes activities. These results were consistent with the presence of histological lesions. A mega-dose of vitamin C is not safe and can cause liver injury
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Ácido Ascórbico
/
Peroxidação de Lipídeos
/
Ratos Wistar
/
Fígado
/
Antioxidantes
Limite:
Animais
Idioma:
Inglês
Revista:
Jordan J. Pharm. Sci.
Ano de publicação:
2012
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