Non-invasive detection of esophageal cancer using genetic changes in circulating cell-free DNA
AJMB-Avicenna Journal of Medical Biotechnology. 2012; 4 (1): 3-13
em Inglês
| IMEMR
| ID: emr-163087
ABSTRACT
Cell free DNA [cfDNA] is a genetic biomarker that is present in serum or plasma in high concentration in many types of cancer. Identification of circu-lating cancer related DNA molecules in serum or plasma is a non-invasive tool for early diagnosis and prognosis in many cancer patients. For this review, study selection and data extraction were performed by the authors. Detection of point mutations, microsatellite alterations, DNA hypermethylations and losses of heterozygosity in circulating cell free DNA have been characterized in esophagus cancer. Application of circulating cell free DNA as a biomarker, provide the best opportunity for constructing non-invasive tests for early detection, prognosis and management of cancer patients, after therapy in many types of cancer
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Índice:
IMEMR (Mediterrâneo Oriental)
Assunto principal:
Prognóstico
/
Neoplasias Esofágicas
/
Biomarcadores Tumorais
/
Detecção Precoce de Câncer
Tipo de estudo:
Estudo de rastreamento
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Avicenna J. Med. Biotechnol.
Ano de publicação:
2012
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