[Invitro comparison studying of dissolution profiles for pharmacopoeial and nonpharmacopoeial native anticonvulsants oral solid dosage forms with brand name]

ABSTRACT

Dissolution is very important parameter in releasing of active pharmaceutical ingredient from dosage form, and this directly correlate with absorption process and consequently with bioavailability of oral dosage forms [tablet]. Oxcarbazepine is an oral anticonvulsant, and in this research we work on Invitro comparison of dissolution protiles for two native oxcarbazepine tablet 300 mg products with the same of patented [trileptal[rigstered]], calculating similarity factor f[2] as the base of comparison, the value of similarity factors were for product-A [f[2]=77.1], for product-B [f[2]=51] appear similarity of dissolution profiles of two previous product with the same of patented